Study of Human Leukocyte Antigen-DR Alleles in Children with Bronchial Asthma in Guangxi Region
- VernacularTitle:广西地区哮喘儿童人类白细胞抗原-DR位点等位基因研究
- Author:
qing-ling, XIE
;
ling, QIN
;
wei, JIAO
;
lin, WANG
;
qiong-yan, HU
;
ying, TAN
;
xiao-chun, LIU
;
yuan-feng, LU
;
hua, DU
- Publication Type:Journal Article
- Keywords:
asthma;
human leucocyte antigen-DR;
alleles;
Guangxi region;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characteristic of the genetic frequency distribution of human leukocyte antigen(HLA)-DR alleles in children with bronchial asthma in Guangxi area.Methods Eighty-four unrelated asthmatic individuals and 168 healthy people without asthma and atopy living in Nanning region of Guangxi as control group were involved in the study.All asthmatics had their serum total IgE levels measured with Pharmacia UniCAP system,and skin-prick test with 10 kinds of inhalant allergens were taken,and pulmonary function were measured among the asthmatic.HLA oligonucleotide array was used to 21 gene frequencies of HLA-DR.Results The frequencies of HLA-DR B1*070X allele and HLA-DR B1*11XX allele among the asthmatic(2.98% and 13.69%)were significantly higher than those in control group(0.3% and 5.95%)(?2 =6.915,9.478 P
