Nuclear Factor Kappa B Involed in Immunologic Function of Critically Ill Newborns
- VernacularTitle:核因子-?B介导危重新生儿免疫功能研究
- Author:
cheng-xiu, WANG
;
zhou, FU
;
qin, XIE
;
li-zhen, FU
- Publication Type:Journal Article
- Keywords:
critically ill;
immunologic function;
nuclear factor kappa B;
infant,newborn
- From:Journal of Applied Clinical Pediatrics
2006;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the immunologic function of critically ill newborn and the relative function of nuclear factor kappa B(NF-?B).Methods The critically ill group contained 50 cases,and 25 cases from healthy newborns were used as control group.Blood samples were collected in each case,levels of cytokine interleukin(IL)-4,interferon(IFN)-?,tumor necrosis factor(TNF)-? and NF-?B were detected.Result Compared with control group,NF-?B of the critically ill newborn activated and the cytokine were disorder,and IL-4 and TNF-? increased,but IFN-? decreased.Conclusions Critically ill newborn exist immune functional disorder.Furthermore,NF-?B activation may be involved in the process in infants with critically illness.
