Significance of Detection of Immunoglobulin E and Interleukin-13 in Asthmatic Children
- VernacularTitle:哮喘患儿免疫球蛋白E、白细胞介素-13检测的意义
- Author:
zhi-hong, WEN
;
wei-ya, ZHOU
;
qiong-yan, HU
;
hua, DU
;
yuan-feng, LU
- Publication Type:Journal Article
- Keywords:
immunoglobulin E;
interleukin-13;
serum;
induced sputum;
asthma;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore roles of total immunoglobulin E(IgE),interleukin-13(IL-13) in asthmatic children,and relation-ship between IgE,IL-13 levels in serum and those in induced sputum.Methods Twenty-six children with asthma who were in chronic persistent period and 20 healthy children were enrolled.Serum and hypertonic saline-induced sputum were obtained in asthmatic children,and serum alone were obtained in control subjects.The levels of IgE were deteced in serum and induced sputum by Pharmacia UniCAP system,and levels of IL-13 were measured by enzyme linked immunosorbent assay(ELISA).Results Asthmatic children had significantly higher serum of IgE and IL-13 levels than those of healthy control group(P0.05).There was positive correlation of IL-13 in serum and induced sputum(r=0.432 P
