Significance of Changes of Serum Beta 2-Microglobulin,Cytocine Levels in Childhood Idiopathic Thrombocytopenic Purpura
- VernacularTitle:特发性血小板减少性紫癜血清?_2微球蛋白及细胞因子水平变化的意义
- Author:
jin-kai, WEI
;
xiao-wei, YANG
;
yu-huan, LIU
;
xuan, SHI
;
yue-hong, XU
- Publication Type:Journal Article
- Keywords:
purpura,thrombocytopenic,idiopathic;
?2-microglobulin;
interleukin-2;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes and significance of serum beta 2-microglobulin(?2-MG),cytocine interleukin-2(IL-2) in the clinical progress of childhood idiopathic thrombocytopenic purpura(ITP).Methods One hundred and ten patients of childhood ITP were chosen for the test group(70 cases of primary ITP and 40 cases of recurrent ITP),and 110 normal children for the control group.Levels of serum ?2-MG and IL-2 were determined by radioimmunoassay kit and analysed with two sample t-test.Results Among the patients,the serum IL-2 levels were significantly lower and serum ?2-MG levels were significantly higher than those in control group(P0.05).Conclusion Determining serum IL-2 and ?2-MG levels has important significance to reflect the progress of disease and direct treatment.
