Changes of Brain Metabolism in Obese Children Using Proton Magnetic Resonance Spectroscopy
- VernacularTitle:中重度肥胖儿童脑代谢的质子磁共振波谱变化
- Author:
ying, SUN
;
fang-biao, TAO
;
yin-feng, QIAN
;
kun, HUANG
- Publication Type:Journal Article
- Keywords:
obesity;
magnetic resonance spectroscopy;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether obese adolescents had neurochemical abnormalities in frontal lobe and hippocampus.Methods Anthropometric indicators were measured in all participants.Proton magnetic resonance spectroscopy(1H-MRS)were performed in 9 obese adolescents and 9 non-obese children as controls.Spectral peaks of N-acetylaspartate(NAA),creatine(Cr),choline(Cho)of 2 cortexes were measured and their ratios were computed and compared.Results Values of NAA and Cho in frontal lobe in obese group were significantly lo-wer than those of controls.There was no significant difference of Cr,NAA/Cr,Cho/Cr in frontal lobe and hippocampus between 2 groups.Conclusion The reduced NAA and Cho on 1H-MRS suggests that amount of neural nerve and myelination of white matter may be harmed in frontal lobe of obese adolescents.
