Relationship between Gastric Acid and Stress Ulcer Produced by Water Immersion in Young Rats
- VernacularTitle:胃酸与幼年大鼠应激性溃疡形成的关系
- Author:
jie, ZHAO
;
wen, ZHANG
;
xiao-mei, TONG
- Publication Type:Journal Article
- Keywords:
stress;
gastric mucosa;
ulcer;
gastric acid
- From:Journal of Applied Clinical Pediatrics
2006;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the animal model with stress ulcer(SU) and probe the relationship between the gastric mucosal injury and lasting stress time,the dynamic structural changes of pH of gastric juice.Methods Twenty-four SD young rats were randomly divided into 4 groups:control group,45 min(groupⅠ),90 min(groupⅡ),3 h(groupⅢ)groups under water immersion restraint stress(WRS).The change of gastric mucosal ulcer index(UI),pH of gastric juice were observed.Results Acute gastric mucosal damage was induced by WRS,with the WRS time prolonged,UI increased gradually and pH of gastric juice remarkably decreased in experimental rats.UI was positively rela-ted with stress time(r=0.957 P
