Permeability and Protective Effect of Nerve Growth Factor by Periphery in Neonatal Rats with Hypoxic-Ischemic Brain Damage
- VernacularTitle:外周应用神经生长因子对新生鼠缺氧脑损伤的保护作用
- Author:
chao-ying, YAN
;
wen-li, ZHOU
;
li-fang, YU
;
hui, WU
- Publication Type:Journal Article
- Keywords:
nerve growth factor;
neonatal rats;
blood-brain barrier;
hypoxia-ischemia;
apoptosis
- From:Journal of Applied Clinical Pediatrics
2006;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the permeability of nerve growth factor(NGF)through blood brain barrier and protective effect of NGF by periphery in neonatal rats with hypoxic-ischemic brain damage(HIBD).Methods The models with HIBD were established and NGF 5 ?g/kg was injected intravenously with 125I,and the permeability of NGF was observed by periphery through blood brain barrier of neonatal rats.Then apoptosis in each group was examined in tissues,samples of frontal cortex and CA1 district in cornu ammonis by TUNEL method.Results The contents of 125I-NGF in neonatal rats and ratio with blood content was higher than those of adult rats,then contents of 125I-NGF in neonatal rats with HIBD and ratio with blood content were higher than those of the neonatal rats(Pa
