Effect of Ligustrazine on Superoxide Dismutase and Malondiade-Hyde after Retinal Ischemia-Reperfusion Injury in Neonatal Rats
- VernacularTitle:川芎嗪对幼鼠缺血-再灌注视网膜超氧化物歧化酶、丙二醛水平的影响
- Author:
jin, JUAN
;
lu, NA
- Publication Type:Journal Article
- Keywords:
ligustrazine;
ischemia-reperfusion;
retina;
neonatal rat
- From:Journal of Applied Clinical Pediatrics
2006;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the protective effect and mechanism of ligustrazine against ischemia-reperfusion injury of retina from neonatal rats.Methods Thirty-two neonatal rats were randomly divided into normal,model,solvent control and ligustrazine treatment group.Experimental model of retinal ischemia-reperfusion injury was established by increasing intraocular pressure through intracameral infusion.In the ligustrazine treatment group,ligustrazine was given by intraperitoneal injecting before 30 min ischmia and after reperfusion 2 hours,10 mg/kg.In the solvent control group,the same voluminal solvent(isotonic Na chloride)was given by the same way before 30 min ischmia and after reperfusion 2 hours.The neonatal rats were executed by aeroembolism after reperfusion 6 hours.The content of malon dialdehyde(MDA) and the superoxide dismutase(SOD) activity were measured by spectrophotometer.Results 1.The content of MDA in model group was significantly higher than that in normal group(t=4.80 P0.05).The SOD activity in model group was significantly lower than that of normal group(t=4.58 P0.05).Conclusion Ligustrazine can protect experimental retinal from ischemia-reperfused injury by increasing SOD activity and decreasing the content of MDA in neonatal rats.
