Significance and Assaying of Serum Interleukin-1?,Interleukin-6,Interleukin-8 and Tumor Necrosis Factor-? in Highly Pathogenic Avian Influenza Viral Pneumonia in Mice
- VernacularTitle:高致病性禽流感病毒性肺炎小鼠模型血清细胞因子的水平
- Author:
hong-xia, ZHAO
;
xian-zhu, XIA
;
ji-rong, LU
- Publication Type:Journal Article
- Keywords:
mice;
highly pathogenic avian influenza virus;
pneumonia;
interleukin-1?;
interleukin-6;
interleukin-8;
tumor necrosis factor-?
- From:Journal of Applied Clinical Pediatrics
2006;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the interrelation between highly pathogenic avian influenza viral pneumonia(HPAIVP) and cellular factors interleukin-1?(IL-1?),interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-?(TNF-?) in HPAIVP.Me-thods Sixty Kunming mice were divided into 2 groups randomly:experiment group and control group,each group consisted of 30 mice.The highly pathogenic avian influenza virus was used to establish HPAIDP models.The expressions of serum IL-1?,IL-6,IL-8 and TNF-? in experiment group of different moment and control group were detected by enzyme linked immunosorbent assay(ELISA).Result The levels of serum IL-1?,IL-6 and TNF-? in experiment group were significantly higher than those in control group(Pa
