Expression of Livin Gene and Its Isoforms in Children with Gliomas
- VernacularTitle:Livin基因及其变构体在儿童脑胶质瘤中的表达
- Author:
qun-li, HE
;
li-qun, MIAO
;
guo-xin, ZHAO
;
bin, GUO
;
xiang, SUN
;
yong-ling, WANG
;
guo-qiang, ZHAO
- Publication Type:Journal Article
- Keywords:
Livin;
inhibitor of apoptosis protein;
fluorescent quantitatied reverse transcription polymerase chain reaction;
gliomas
- From:Journal of Applied Clinical Pediatrics
2006;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of novel inhibitor of apoptosis protein(IAP) family member livin gene and its two isoforms(livin ? and livin ?) in brain tissue of children with gliomas.Methods Livin ? and Livin ? mRNA were detected by real time fluorescent quantitative reverse transcription polymerase chain reaction(RT-PCR) in brain tissue of 30 children with gliomas and 12 healthy children.Result The positive rate of Livin mRNA expression was 83.3%(25/30 cases)in 30 cases of children with gliomas,the positive rate of Livin mRNA was only 8.3%(1/12 case) in normal brain tissue,there was significant difference in 2 groups(P
