Expression of Intercellular Adhesion Molecule-1 in Brain Edema Induced by Lipoposacchride in Rats under Action of Dexamethasone
- VernacularTitle:地塞米松作用下细胞间黏附分子-1在脂多糖致脑水肿大鼠脑组织中表达的变化
- Author:
xiang, ZOU
;
jun-ping, LU
;
huai-li, WANG
;
tie-zheng, GAO
- Publication Type:Journal Article
- Keywords:
lipoposacchride;
brain edema;
intercellular adhesion molecule-1;
dexamethasone
- From:Journal of Applied Clinical Pediatrics
2006;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of intercellular adhesion molecule-1(ICAM-1) in the brain edema induced by lipoposacchride(LPS) in rats under the action of dexamethasone.Methods One hundred and fifty healthy SD rats were randomly divided into three groups of 50 each:normal saline group(NS group),LPS group and dexamethasone group(DXM group).Each group were again divided into 5 groups:4,6,12,24 and 48 h group.Brain edema was induced by LPS.Immunohistochemistry staining methods were used to measure the expression of ICAM-1 in brain tissue of brain edema induced by LPS in rats.And the level of evans blue(EB) was aslo determined.Results At each time point,the content of brain tissue and evans blue(EB) in LPS and DXM group all increased significantly than those in NS group(Pa0.05).In LPS group,brain water content and EB content,expressing quantity of ICAM-1 and brain water content,expressing quantity of ICAM-1 and EB content all had positive relationship(r=0.537,0.467,0.549 Pa
