Expression of Fas/FasL in Children with Aplastic Anemia and Its Clinical Significance
- VernacularTitle:Fas/FasL在再生障碍性贫血患儿中的表达及意义
- Author:
xiao-qing, ZHAO
;
bao-xi, ZHANG
;
xiao-li, WU
- Publication Type:Journal Article
- Keywords:
anemia,aplastic;
CD_(34)~+ cell;
Fas;
FasL;
flow cytometry;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Fas/FasL in children with aplastic anemia(AA) and its clinical significance.To explore the pathogenesis of AA.Methods CD34+ cell counts and the expression of Fas/FasL in 12 children with severe AA(SAA),18 with chronic AA(CAA)and 10 normal children were detected by flow cytometry combining monocolon antibody.Results The expression of Fas in children with AA were significantly higher than that in control group(P0.05).Conclusions Fas/FasL systeam take part in inducing CD34+ cell apoptosis.This may contribute to understanding the decrease number of stem cells and bone marrow failure.
