Antithymocyte Globulin Combining Cyclosporin in Treatment of Pediatric Severe Aplastic Anemia
- VernacularTitle:抗胸腺球蛋白联合环孢素治疗儿童重型再生障碍性贫血
- Author:
xuan, ZHOU
;
run-hui, WU
;
yan-long, DUAN
- Publication Type:Journal Article
- Keywords:
severe aplastic anemia;
antithymocyte;
cyclosporin;
immunosuppressive treatment;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effectiveness of antithymocyte globulin(ATG) combined with cyclosporin(CSA)in treatment of pediatric severe aplastic anemia(SAA).Methods Seven children with SAA were treated with ATG and CSA,ATG 4-5 mg/(kg?d),5 days,methyprednisone 2-3 mg/(kg?d) to reduce anaphylaxis,CSA 3-5 mg/(kg?d),assisting with transfusion and G-CSF.Results The complete remission rate was 28.57%(2/7),the partial remission rate was 14.29%(1/7),and the obvious improvement rate was 28.57%(2/7),1 child died.The overall response rate was 71.43%.Transfusion volumes in 4 to 6 months post treatment decreased obviously comparing to the first 3 months(P
