Expression of Cyclooxygenase-2 and Survivin in Children with Acute Leukemia and Its Significance
- VernacularTitle:急性白血病患儿骨髓细胞环氧合酶-2和survivin表达及其意义
- Author:
yan-qing, SONG
;
qun, HU
;
hua-xiong, PAN
;
ai-guo, LIU
;
liu-qing, ZHANG
;
xiao-ling, ZHANG
;
ying, HU
;
hong-fang, TAO
- Publication Type:Journal Article
- Keywords:
acute leukemia;
cyclooxygenase-2;
survivin;
immunochemistry
- From:Journal of Applied Clinical Pediatrics
2006;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of cyclooxygenase-2(COX-2) and survivin in children with acute leukemia(AL) and its significance.Method The expression of COX-2 and survivin were determined by immunohistochemical SABC assay.Results The expression rate of COX-2 and survivin were 52.4%(22/42 cases)and 45.2%(19/42 cases)in AL,and the expression rate of COX-2 and survivin were 46.9%(15/32 cases)and 40.6%(13/32 cases)and in acute lymphonate leukemia(ALL),both of them were higher than those in control group(Pa0.05).The positive rate of COX-2 was 84%(16/19 cases)in 19 cases with survivin positive expression,and the negative rate of COX-2 was 85%(17/20 cases)in 20 cases with survivin negative expression,and there was positive correlation between COX-2 expression and survivin expression(r=0.579 P
