Comparison of Effects of Antenatal Ambroxol and Dexamethasone on Rats′ Fetal Lung Morphogenesis
- VernacularTitle:盐酸氨溴索、地塞米松产前用药对大鼠胎肺形态发育影响的对比
- Author:
qing, KAN
;
xiao-yu, ZHOU
;
xiao-qi, GU
;
ru, LIU
;
xi-rong, GUO
- Publication Type:Journal Article
- Keywords:
ambroxol;
dexamethasone;
fetal lung;
morphogenesis
- From:Journal of Applied Clinical Pediatrics
2006;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of antenatal ambroxol and 3-day dexamethasone and 1-day dexamethasone on rats′ fetal lung morphogenesis.Methods Twelve pregnant rats were divided into 4 groups randomly:3-day ambroxol group,3-day dexamethasone group,1-day dexamethasone group and control group,every group had 3 rats.On gestational day 19,cesareans were carried out and the histologic structures of 6 fetal rats lungs of each pregnant rats were observed with light microscope,electronic microscope and image analysis.Results 1.Under the light microscope,compared with control group,fetal rats lung in three treatment groups had more alveolar numbers,larger alveolar space,and thinner alveolar septum(Pa