Expression of Nuclear Factor ?B and Its Relationship with Apoptosis of Hippocampus in Neonatal Rats with Hypoxia-Ischemia Brain Damage
- VernacularTitle:缺氧缺血性脑损伤新生大鼠核因子?B表达与脑细胞凋亡的关系
- Author:
ling, TAN
;
juan, CHEN
;
zhi, LIAO
- Publication Type:Journal Article
- Keywords:
rat,newborn;
hypoxia-ischemia;
brain damage;
nuclear factor ?B;
apoptosis
- From:Journal of Applied Clinical Pediatrics
2006;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the correlation between nuclear factor ?B(NF-?B) expression and apoptosis after hypoxia-ischemia brain damage(HIBD).Methods Forty-eight 7-day newborn Sprague-Dawley(SD) rats were randomly divided into 2 groups: control group (n=24) and HI group (n=24).The expression of NF-?B in the hippocampus was detected by immunohistochemical techniques.The apoptosis of the hippocampal cells was detected by terminal deoxynucleotidyltransferase-mediated 2-deoxyuridine 5′-triphosphate-biotin nick end labeling(TUNEL)straining.Results The expression of NF-?B in hippocampal cells increased at 6 h after HIBD,peaked at 48 h,and lasted till 72 h when compared with control group(Pa
