Expression of c-fos Protein in Hippocampus of Newborn Rats with Hypoxic-Ischemic Brain Damage and Its Significance
- VernacularTitle:缺氧缺血性脑损伤新生大鼠c-fos蛋白表达的意义
- Author:
ming-li, JI
;
zhi-bin, QIAN
;
yu-xia, WANG
;
quan-zhong, CHANG
- Publication Type:Journal Article
- Keywords:
rat,newborn;
hypoxic-ischemic brain;
c-fos protein;
apoptosis
- From:Journal of Applied Clinical Pediatrics
2006;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of c-fos protein and cell apoptosis by observing the expression of c-fos protein in hippocampus of newborn rat with hypoxic-ischemic brain damage(HIBD).Methods Forty-eight 7-day SD neonatal rats were randomly divided into control group(n=6) and experiment group(n=42).The models of HIBD were established in neonatal rats by inhaling the mixed gases of 920 mL/L N2 and 80 mL/L O2,and the animals were sacrificed by dislocation their heads at different time points(0.5,1,3,6,12,24,48,72 h),then the hippocampus were dissected by morphological analysis.Results The apoptotic cells appeared at the time point of 3 h,and reached the peak at 48 h,then decreased.The positive cell of c-fos protein increased from the time point of 30 min and reached the peak at 2 h and then decreased gradually,and there was a contrary tendency between the expression of c-fos protein and the number of damaged brain cells by HIBD(r=-0.57 P
