Influence of Lamotrigine and Valproate on Cognitive Function in Children with Epilepsy
- VernacularTitle:拉莫三嗪、丙戊酸钠对癫儿童认知功能的影响
- Author:
guan-hui, LI
;
rong-fu, SHI
;
rong, WANG
;
gui-xiang, PANG
;
jian-ying, LI
;
qing-hua, LI
- Publication Type:Journal Article
- Keywords:
epilepsy;
child;
valproate;
lamotrigine;
cognition
- From:Journal of Applied Clinical Pediatrics
2004;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of lamotrigine(LTG)and valproate(VAP)on cognitive function in children with epilepsy.Methods Seventy-six epileptic children firstly diagnosed were chosen,36 cases received LTG monotherapy and 40 cases undwent the treatment of VPA.The intelligence quotient(IQ)value was measured before and after 6 months treatment respectively,and 20 healthy children were selected as healthy control.Results 1.The epileptic children had poor verbal intelligence quotient(VIQ),performance intelligence quotient(PIQ)and full intelligence quotient(FIQ)compared to the control subjects(Pa0.05).But among the subtestings,the know-ledge,wood-graph,coded score of the VPA groups had significant difference(Pa
