Therapeutic Effects of Low-Dose Topiramate on Children with Tourette Syndrome
- VernacularTitle:小剂量托吡酯治疗Tourette综合征的效果
- Author:
guang-yu, LIN
;
li-min, LIN
;
yu-sheng, LIN
;
yi, WU
;
pai-zhen, CHEN
;
wan-li, ZHUANG
;
lian, MA
- Publication Type:Journal Article
- Keywords:
Tourette syndrome;
therapy;
topiramate;
dose
- From:Journal of Applied Clinical Pediatrics
2004;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the therapeutic effects and dose of Topiramate(TPM)in children with Tourette syndrome(TS).Me-thods Seventy-nine children with TS were given oral TPM,which were treated with Topiramate [0.5-3.0 mg/(kg?d),twice a day].The therapeutic effects were assessed using Yale Global Tic Severity Scale(YGTSS)before and 3 months after treatment and the side-effects of the drugs were observed.Results The differences of YGTSS scores before and after treatment,motertic score(19.63?3.09 vs 5.05?1.74),vocaltic score[(18.95?2.56)vs(4.82?1.94)],global scole score[(24.21?5.89)vs(10.42?3.69)],severity score[(62.21?5.81)vs(22.26?4.81)],there were significant differences of every score of YGTSS between before and after treatment(Pa
