Cellular and Humoral Immunity in Children with Recurrent Respiratory Tract Infection
- VernacularTitle:反复呼吸道感染儿童细胞免疫与体液免疫状况
- Author:
rui-zhu, HAN
;
yan-yan, HAO
;
an-cun, HOU
- Publication Type:Journal Article
- Keywords:
recurrent respiratory tract infection;
T lymphocyte subsets;
immunoglobulin;
complement
- From:Journal of Applied Clinical Pediatrics
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the cellular and humoral immunity in children with recurrent respiratory tract infection(RRI).Methods Fresh peripheral blood samples were treated and run through the flow cytometry,the percentage of lymphocytes subsets were acquired using Simultest software simulaneously. Immunoglobulin IgA,IgG,IgM and complement C3 and C4 were measured.Results The levels of IgG and IgA in the RRI group were lower than the normal reference value in only 1 patient respectively.The level of IgM decreased in 7cases.Complement C3 and C4 decreased in 3 and 1 patients, respectively.The percentage of CD8 in the RRI group was higher than that in healthy control group(P=0),and the CD4/CD8 was obviously lower than that in healthy control group(P=0.002).Conclusions The disorder of cellular and humoral immunity are existing and cell-mediated immune disorder is more obviously in RRI.The immune-modulation agents are necessary in the prevention and treatment for RRI.
