Influence of Inhaling Glucocorticoid on Imbalance of Interleukin-4/Interferon-? of Infant with First Onset Wheezing
- VernacularTitle:吸入糖皮质激素对首次发作喘息患儿白细胞介素4/干扰素?失衡的影响
- Author:
jun, LI
;
jing-zhi, JI
;
xue-hua, ZHANG
- Publication Type:Journal Article
- Keywords:
couticoseroid;
asthma;
interleukin-4;
interferon-?
- From:Journal of Applied Clinical Pediatrics
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the regulating effect of inhaling glucocorticoid on imbalance of IL-4/interferon-?(IFN-?) cytokines in children with first onset wheezing .Methods IL-4 and IFN-? levels were examined in separated serum of 60 children wheezing with first onset wheezing,they were divided into abnormal level of IL-4/IFN-? group (n=38) and normal level of IL-4/IFN-? group(n=22,group C) depending on the level of IL-4/IFN-?,and 38 cases with abnormal level of IL-4/IFN-? were randomly divided into group A and B.Group B and C were given routine treatment without intervening treatment,while group A inhaled beclomethasone dipropionate aerosols for 3 months after routine treatment.Twenty healthy children for routine physical examinations in the same period were selected as healthy control group,who were examined for IL-4 and IFN-? with the same methods.Results Before treatment,the levels of IL-4 and IL-4/IFN-? in group A and B were significantly higher than those in group C and healthy control group(Pa
