Clinical Significance of Induced Sputum Clara Cell Secretory Protein and Eosinophil Cationic Protein in Children with Bronchial Asthma
- VernacularTitle:哮喘患儿诱导痰Clara细胞分泌蛋白与嗜酸性粒细胞阳离子蛋白检测的意义
- Author:
zhi-hong, WEN
;
wei-ya, ZHOU
;
qiong-yan, HU
;
hua, DU
;
yuan-feng, LU
- Publication Type:Journal Article
- Keywords:
clara cell secretory protein;
eosinophil cationic protein;
induced sputum;
asthma;
child
- From:Journal of Applied Clinical Pediatrics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the roles of clara cell secretory protein(CCSP)and eosinophil cationic protein(ECP)in the pathoge-nesis of bronchial asthma and to evaluate their diagnostic value in asthmatic children.Methods Induced sputum samples were obtained from 31 asthmatic children during chronic persistent period and clinical remission period.According to global initiative for asthma(GINA),the total of 31 cases accepted systemic treatment by inhaling glucocorticoid.The patients included 18 boys and 13 girls aged from 3.7 to 12.0 years,and their average age was 7.6 years.Sputum CCSP concentrations were measured by enzyme-linked immunosorbent assay(ELISA).And the concentrations of sputum ECP were determined with Pharmacia UniCAP system.Results Asthmatic children had significantly lower CCSP levels in sputum during chronic persistent period compared with clinical remission period(P
