Effects of Leukotriene B4-Leukotriene B4 Receptor Pathway in Vascular Immunizing Damage of Kawasaki Disease
- VernacularTitle:白三烯受体途径在川崎病血管免疫损伤中的作用
- Author:
yuan-xiang, WEI
;
hong-wei, WANG
;
min, KANG
- Publication Type:Journal Article
- Keywords:
mucocutaneous lymph node syndrome;
leukotriene B4-leukotriene B4 receptor pathway;
?-globulin
- From:Journal of Applied Clinical Pediatrics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of serum in children with Kawasaki disease(KD)in acute stage and ?-globulin role in monocyte cell-produced leukotriene B4(LTB4).Meanwhile,to investigate the effects of the monocyte cell conditioned media(MCM)on the expression of leukotriene B4 receptor 2(BLT2)in endothelial.In order to understand whether LTB4-BLT2 pathway gets involved in vascular damage in KD and the mechanism of ?-globulin in the lessening vascular damage of KD.Methods The concentration of LTB4 in cell culture after the stimulation by serum of healthy children,serum of acute KD and serum of acute KD with ?-globulin were observed,respectively.The expression of BLT2 in the endothelial was determined by flow cytometry.Results 1.The serum of children with KD increased the concentration of LTB4 in MCM(P
