Effects of Corticosteroid on Expression of Nerve Growth Factor in Lungs of Asthmatic Rats
- VernacularTitle:糖皮质激素对哮喘大鼠肺神经生长因子表达的影响
- Author:
yan, ZHANG
;
li-ping, ZOU
;
bin, LUAN
;
su-ge, HAN
- Publication Type:Journal Article
- Keywords:
asthma;
nerve growth factor;
corticosteriod;
rat
- From:Journal of Applied Clinical Pediatrics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of nerve growth factor(NGF)in asthmatic rats by observing the expression of NGF and effects of corticosteroid on the expression of NGF in lungs of asthmatic rats.Methods Forty-five rats were randomly devided into 3 groups:control group,asthmatic group,therapeutic group with corticosteroid.The thickness of airway smooth musle(ASM)was measured by HE staining,and the expression of NGF was observed by immunohistochemical staining.Results 1.The thickness of ASM,the expression of NGF and were significantly higher in asthmatic group than those of control group and therapeutic group(Pa
