Preventive Effect of Mannatide on Relapsing of Idiopathic Thrombocytoperlic Purura
- VernacularTitle:甘露聚糖肽对预防特发性血小板减少性紫癜复发的作用
- Author:
de-zheng, LAN
;
xian-liang, SONG
- Publication Type:Journal Article
- Keywords:
mannans;
purpura,thrombocytopenic,idiopathic;
immunoglobulin;
recurrence
- From:Journal of Applied Clinical Pediatrics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the preventive effect of mannatide on infection and relapse of idiopathic thrombocytopenic purura(ITP).Methods One hundred and twenty children with ITP were randomly divided into mannatide treatment group and prednisone control group.Control group venous dexamethasone of 3 d;then treated by prednisone.Treatment group added mannatide tablets for 1 month.The rates of remission clinical blood,platelet,control time,complicated infection and relapse rates were observed.The levels of plasma immunoglobulin(Ig)G,IgA,IgM were determined before and after mannatide treatment.Results The rate of clinical blood,platelet,control time,infection time was not different in 2 groups.The rates of infection complicated and relapse were all significant lower than that in control group.The plasma IgG,IgA significantly increased than that in control group.The plasma IgM had no significant difference.Conclusion Vaccine therapy can be helpful in protecting and decreasing infection,diminishing relapse of children with ITP,and improve the level of IgG,IgA,and thus improve their immune function.
