Changes of Serum Growth Hormone,Insulin-Like Growth Factor-Ⅰ and Insulin-Like Growth Factor Binding Portein-3 Levels in Children with Hypothyroidism
- VernacularTitle:甲状腺功能减退症患儿血清生长激素、胰岛素样生长因子-Ⅰ、胰岛素样生长因子结合蛋白-3水平的变化
- Author:
xu, XU
;
yong, HE
;
hong, SHA
;
bo-ru, MEI
- Publication Type:Journal Article
- Keywords:
hypothyroidism;
insulin-like growth factor-I;
insulin-like growth factor binging protein-3
- From:Journal of Applied Clinical Pediatrics
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the serum growth hormone(GH),insulin-like growth factor-I(IGF-Ⅰ),insulin-like growth factor binging protein-3(IGFBP-3) levels in children with hypothyroidism and explore the change regulation of GH-IGF axis and thyroxine.Methods Fifty-six hypothyroidism children were divided into congonital hypothyroidism(CH)(14 cases) and Hashimoto's thyroiditis(32 cases).Serum GH,IGF-Ⅰ,IGFBP-3 levels of 56 hypothyroidism children before and after luothyroxine sodium L-T4 treatment and 50 normal children were detected with radioimmunoassay or enzyme-linked immunosorbent assay methods.Results Serum IGF-I,IGFBP-3 levels in 9 CH newborn group were lower,and they were normal after thyroxine substitute therapy.But those of 5 children with CH and 32 cases with Hashimoto's thyroiditis were not significantly changed.Conclusions The GH-IGF axis is inordinate in the CH children,which is an important reason of stature short.Early thyroxine substitute therapy is very helpful to maintain normal growth and development of children with CH.
