Effect of Metformin Therapy on Obese Nondiabetic Children with Hyperinsulinemia
- VernacularTitle:二甲双胍治疗肥胖伴高胰岛素血症非糖尿病儿童疗效
- Author:
pei-rong, YANG
;
xiao-dong, HUANG
;
yong-nian, SHEN
- Publication Type:Journal Article
- Keywords:
metformin;
obesity;
hyperinsulinemia
- From:Journal of Applied Clinical Pediatrics
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy and safety of metformin therapy on obese nondiabetic children with hyperinsulinemia.Methods Twenty-two obese nondiabetic children with hyperinsulinemia were divided into two groups:control group(dietary counseling and exercise) and treatment group(dietary counseling and exercise combined with metformin).The changes of body mass index(BMI),fasting glucose(FPG),fasting insulin(FINS),insulin resistance(HOMA-IR),2 h PG,2 h INS,total cholesterol(TC) and triglyceride(TG),before and after treatment were determined,and the findings were compared and analyzed.Results After treatment,there were significant differences in BMI,TC,FINS,HOMA-IR levels(P0.05),except the BMI(P
