Effects of Ligustrazine on Secretion of Nitric Oxide in Ventricular Tissues of Rats under Physiological Condition
- VernacularTitle:川芎嗪注射液对生理状态下大鼠心室组织一氧化氮分泌的影响
- Author:
qian-jin, ZHANG
;
yan-fei, WANG
;
jun-bao, DU
- Publication Type:Journal Article
- Keywords:
ligustrazine;
nitric oxide;
ventricular;
incubation
- From:Journal of Applied Clinical Pediatrics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of ligustrazine on secretion of nitric oxide(NO) in ventricular tissues of rats under physiologi-cal condition.Methods Twenty-four normal wistar rats were divided into three groups,eight each group.The left and right ventricular tissues of each rats were divided into control group and 2 ligustrazine groups and the final concentrations of ligustrazine were 15 mg/L and 150 mg/L respectively.The ventricular tissues that had been cutting into small pieces were incubated in 37 ℃ thermostatic water bath for 4 hours with Krebs solution as supernatant.After incubation of the ventricular tissues,the spectrophotometric method was used to detect the content of NO_2~-/NO_3~-in the supernatant.Results Compared with the content of NO in control group,it was significantly decreased in the 150 mg/L ligustrazine group(P
