Expression and Role of Vascular Endothelial Growth Factor in Pulmonary Tissue of Newborn Rats with Pulmonary Hemorrhage
- VernacularTitle:血管内皮生长因子在肺出血新生鼠肺组织中的表达及其作用
- Author:
yu-jun, CHEN
;
ke-zheng, CHEN
;
tang-wei, LIU
;
yu-sheng, PANG
- Publication Type:Journal Article
- Keywords:
vascular endothelial growth factor;
pulmonary hemorrhage;
rat,newborn
- From:Journal of Applied Clinical Pediatrics
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
95 mL/L O2) for 2 hours.The gross anatomical and histological changes(HE staining)in lungs were observed,VEGF mRNA expressions were studied by reverse transcription polymerase chain reaction(RT-PCR).Results Lungs of experimental groups represented edema,inaddition,punctiform,local and diffuse pulmonary hemorrhage were observed in groups of HH,HHR and HHRO2.Histopathological changes included pulmonary alveoli and interstitial edema,spacer breaking,pulmonary alveolidilating,fusion and hemorrhage,in which the most severe cases involved in group HHRO2.VEGF 188 mRNA expression increased significantly in group H and HH(P
