Effects of Low-Molecular-Weight Heparin on Respiratory Syncytial Virus Nephropathy in Rats
- VernacularTitle:低分子肝素对呼吸道合胞病毒肾病大鼠模型的影响
- Author:
yan-nan, GUO
;
zheng, WANG
;
xiao-ming, LIU
- Publication Type:Journal Article
- Keywords:
respiratory syncytial virus;
heparitin sulfate;
heparin,low-molecular-weight;
kidney diseases;
rat
- From:Journal of Applied Clinical Pediatrics
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).3.Under light microscope, there was no change of the glomeruli detected in all of the LMWH-treated groups compared with the controls,while congestion and swel-ling in part glomeruli of group RSV were observed significantly. 4.Under electron microscope,glomerular structures of the LMWH-treated groups were almost normal compared with the control, while extensive foot process effacement was observed in group RSV under an electron microscope. 5.RSV RNA signal expressed weaker in the LMWH-treated groups than in group RSV.Conclusions Positive charged RSV destroys the glome-rular filtration barrier through its electrostatic interaction with the negative charged heparan sulfate(HS) of GBM. LMWH, as the analog of HS, charged with anion, competes with GBM HS to combine with RSV to keep the glomeruli from being infected and destroyed, and then reduce the proteinuria.
