Expression of Heat-Shock Protein 70 in Kidney of Acute Injury Rats Caused by Gentamicin
- VernacularTitle:庆大霉素诱导急性肾损伤大鼠肾脏热休克蛋白70的表达
- Author:
hong-yan, ZHANG
;
ling-di, SUN
;
da-ya, ZHAO
- Publication Type:Journal Article
- Keywords:
gentamicin;
renal injury;
heat-shock protein 70;
rat
- From:Journal of Applied Clinical Pediatrics
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To illustrate the expressional distribution of heat shock protein 70(HSP 70) in the kidney of acute renal injury rats caused by gentamicin.Methods One hundred and fifty rats were randomly divided into 3 groups: group A (normal group), group B [80 mg/(kg?d) gentamicin to be injected], group C [160 mg/(kg?d) gentamicin to be given]. The variations of renal pathology were observed at different time phasess by light scope and electromicroscope. Simultaneously, the expression of HSP 70 in kidney was evaluated by immunohistochemistry.Results HSP 70 distributed in epithelial cells of renal tubular in acute injury rats. The expression of HSP 70 increased markedly from the 6th hour after injection, peaked at the 12th hour and lasted for 48 hours. The expression of HSP 70 in group C was higher than that in group B(P
