Effect of Lovastatin on Plasminogen Activator Inhibitor-1 and Collagen Type Ⅳ in Rats with Glomerularsclerosis
- VernacularTitle:洛伐他汀对肾小球硬化大鼠纤溶酶原激活物抑制剂-1和Ⅳ型胶原表达的影响
- Author:
he, ZHANG
;
zi-ming, HAN
;
da-sheng, YANG
- Publication Type:Journal Article
- Keywords:
lovastatin;
glomerularsclerosis;
plasminogen activator inhibitor-1;
collagen type Ⅳ
- From:Journal of Applied Clinical Pediatrics
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of lovastatin on plasminogen activator inhibitor -1 (PAI-1) and collagen type Ⅳ in rats with glomerularsclerosis induced by adriamycin,and to discuss its mechanism of protective effects on kidneys.Methods Twenty-four male Wistar nephritic rats induced by adriamycin were randomly divided into 3 groups:control,hyperlipidemia and lovastatin treatment group.They were fed 12 weeks.Urinary protein excretion and serum lipid were assayed,then renal glomerularsclerosis index,the expression of PAI-1 and collagen type Ⅳ were observed.Results Serum total cholesterol,triglycerides,low-density lipoprotein,urinary protein excretion,renal glomerularsclerosis index were significantly lower in treatment group than those in hyperlipidemia group.Expression of PAI-1 and collagen type Ⅳ,and number of foamcells were also sharply lower in treatment group than those in hyperlipidemia group.Conclusions Lovastatin not only reduces proteinuria,improves renal function,but also modulates glomerularsclerosis by inhibiting activity of PAI-1 and decreasing accumulation of collagen type Ⅳ.The mechanism of renal protective effect is independent of a reduction of circulating cholesterol.
