Significance of Changes of Interleukin-18 Expression Levels of Serum and Peripheral Blood Mononuclear Cells in Children with Steroid-Sensitive Nephrotic Syndrome
- VernacularTitle:激素敏感型肾病综合征患儿血清、外周血单个核细胞白细胞介素-18表达的意义
- Author:
hong-zhu, LU
;
xiao-hong, WU
;
wan-ming, ZHANG
;
yue-sha, YUAN
;
dan, LIU
- Publication Type:Journal Article
- Keywords:
nephrotic syndrome;
interleukin-18;
peripheral blood mononuclear cells;
child
- From:Journal of Applied Clinical Pediatrics
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the steroid-sensitive nephrotic syndrome(SSNS) and interleukin-18(IL-18) and to approach the inhibitive role of dexamethasone(DEX) on expression of IL-18 of peripheral blood mononuclear cells(PBMC) in children with SSNS in vitro.Methods IL-18 levels of serum, urine and supernatants of PBMC cultured in vitro were measured by enzyme linked immunosorbent assay(ELISA) in 23 children with SSNS who were either before or after treatment. Fifteen age-matched healthy children served as normal control group, and another 18 children with respiratory infections as infectious control group.Results There were signi-ficant differences of IL-18 in serum and urine before and after treatment in children with SSNS (t=15.072,16.149 Pa
