Effect of Hydrogen Peroxide on Microstructure of Mice Kidney
- VernacularTitle:过氧化氢摄入对小鼠肾脏显微结构的影响
- Author:
quan-xiang, MA
;
ze-shan, MAO
;
xiang-shan, YUAN
;
jin-zhu, HAN
;
ting-tong, YANG
- Publication Type:Journal Article
- Keywords:
hydrogen peroxide;
kidney;
microstructure;
mouse
- From:Journal of Applied Clinical Pediatrics
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of hydrogen peroxide on microstructure of mice kidney and discuss the toxic effect on mice kidney.Methods Thirty healthy male mice of Kunming Genus were divided into 3 groups at random:control group and two experimental groups. Running water was fed to control group for 10 days while 0.3,3 g/L hydrogen peroxide running water readily prepared was fed to the experimental groups for 10 days. On the 10th day,the kidneys were taken out,and fixed in the fixation solutions,conventionally produced and stained.Finally,they were studied under the optical microscope.Results Experimental groups:in the kidney tissue cytoplasm of proximal convoluted tubule showed hydropic degeneration and vacuolation which depend on dose of hydrogen peroxide.Conclusion Toxic effect on mice kidney can be caused by hydrogen peroxide.
