Significance of Determining Interleukin-17,Matrix Metalloproteinases-9 and Immunoglobulin E in Serum of Asthmatic Children
- VernacularTitle:哮喘患儿血清白细胞介素17、基质金属蛋白酶-9和免疫球蛋白E水平测定的意义
- Author:
hong-wei, WANG
;
shu-qiang, QU
;
jun, GAO
;
feng-xia, ZHANG
- Publication Type:Journal Article
- Keywords:
asthma;
interleukin-17;
matrix metalloproteinases-9
- From:Journal of Applied Clinical Pediatrics
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of the levels of interleukin-17(IL-17),matrix metalloproteinases-9(MMP-9) and immunoglobulin E(IgE) in serum of asthmatic children and analyzing the correlation.Methods Twenty-eight asthmatic children and 14 healthy children were collected to determin the levels of IL-17,MMP-9 by sandwich enzyme linked immunosorbent assay,and the correlation of IL-17,MMP-9 and IgE in serum were analyzed.Results The levels of IL-17,MMP-9 and total IgE in serum of asthmatic children were significantly higher than that of control group(Pa0.05).Conclusions The levels of IL-17 and MMP-9 increase in asthmatic airway inflammation.IL-17 and MMP-9 play an important role in asthmatic airway inflammation and airway rebuilding.
