Immunophenotypic Features of NK/T Cell Lymphoma in Children and Its Association with Epstein-Barr Virus
- VernacularTitle:儿童NK/T细胞淋巴瘤的免疫表型及其与EB病毒的关系
- Author:
wei-xing, GUI
;
meng, MING
;
da-bin, WANG
;
dian-ding, ZOU
;
jian-hua, YI
;
jian, ZHANG
- Publication Type:Journal Article
- Keywords:
NK/T cell lymphoma;
epstein-barr virus;
immunohistochemistry;
in situ hybridization
- From:Journal of Applied Clinical Pediatrics
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the immunophenotypic features of NK/T cell lymphoma in children and its association with Epstein-Barr virus (EBV) infection. Methods Five cases of children′s NK/T cell lymphoma were studied. CD45RO, CD3?, CD56, CD20, TIA-1 and granzyme B were detected by immunohistochemistry staining for investigating immunophenotype. The expression of EBV-latent membrane protein (LMP-1) were detected by immunohistochemistry. EBV-encoded RNA (EBER1/2) were detected by in situ hybridization (ISH). Results CD45RO, CD3?, TIA-1 and granzyme B were positive in 5 cases, CD56 was positive in 2 cases, while CD20 negative in 5 cases.EBER1/2 positive in 4 cases and LMP-1 positive in 3 cases.Conclusions NK/T cell lymphoma in children is strong associated with EBV infection,and EBV infection may play an important role in the pathogenesis of children NK/T cell lymphoma.
