Immunophenotype of Children with Acute Myeloid Leukemia and Its Clinical Significance
- VernacularTitle:急性粒细胞白血病患儿免疫表型及其临床意义
- Author:
cai-feng, LIU
;
gui-lan, LIU
;
yi-fei, CHENG
;
ai-dong, LU
;
le-ping, ZHANG
- Publication Type:Journal Article
- Keywords:
child;
acute myeloid leukemia;
immunophenotype;
prognosis
- From:Journal of Applied Clinical Pediatrics
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the immunophenotype of children with acute myeloid leukemia(AML) and its clinical significance.Methods Statistics was used to analyze the relationship between the immunophenotype of AML and their French-American-Britain(FAB) classification,complete remission (CR) in one month and 3-years event-free survival(EFS).Results CR rate was 71.6% and 3-years EFS rate was 50.8%. HLA-DR and CD34 absent mainly in M3, associated with higher CR and EFS rate. So did CD33 negative cases, especially in M2. CD13 positive was significantly predictive factor for achieving CR.Co-expression of lymphoid antigens and NK cell antigens(CD56) with M2 which correlated with lower CR and EFS rate.Conclusions The negative of HLA-DR, CD34, CD33,as well as CD13 positive, have relationship with good prognosis. Lymphoid antigens and CD56 are poor prognostic factors.
