Expression of Insulin-Like Growth Factor-Binding Protein-5 in Full-Term Rats with Hyperoxia-Induced Chronic Lung Diseases and Its Machanism
- VernacularTitle:胰岛素样生长因子结合蛋白5在高体积分数氧致新生鼠慢性肺疾病的表达及其作用机制
- Author:
dan, LIU
;
xin-dong, XUE
- Publication Type:Journal Article
- Keywords:
insulin-like growth factors-binding protein-5;
chronic lung disease;
extracellular matrix
- From:Journal of Applied Clinical Pediatrics
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of insulin-like growth factor-binding protein-5( IGFBP-5) in full-term rats with hyperoxia-induced chronic lung diseases(CLD) and its mechanism.Methods Ninety-six full-term rats were randomly exposed to hyperoxia (hyperoxia group)and room air(room air group).CLD was induced by hyperoxia exposure.RT-PCR and immunohistochemical metho -ds were used to detect the expression of IGFBP-5 at 1,3,7,10 ,14 and 21 days after exposure.Results The expression of IGFBP -5 was dynamic, the expression of IGFBP-5 increased significantly in hyperoxia group compared with room air group at 3 d to 10 d after hyperoxia exposure (P
