Expression of Notch2,Notch4 in Hyperoxia Induced Lung Injury in Premature Rats
- VernacularTitle:Notch2、Notch4在新生早产大鼠高氧肺损伤中的表达
- Author:
chun-mei, LIU
;
li-wen, CHANG
;
jing, LIU
- Publication Type:Journal Article
- Keywords:
Notch2;
Notch4;
rat,premature;
hyperbaric oxygenation;
lung injury
- From:Journal of Applied Clinical Pediatrics
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the roles of Notch2,Notch4 in hyperoxia induced lung injury in premature rats.Methods At the postnatal 1 day Sprague-Dawley premature rats were randomly assigned to about 85% hyperoxia group and air group.At the 1,7,14,21 days after exposed,8 rats of each group were used to evaluate expressions of Notch2,Notch4 in lungs by immunohistochemistry and the level of Nothch2,Notch4 mRNA by reverse transcription polymerase chain reaction(RT-PCR).Results Expressions of Notch2,Notch4 had their rules in rats′ different stages of development;85% oxygen exposed would change their tracks.Conclusion Prolonged 85% oxygen exposure result in abnormal expressions of Notch2 and Notch4 ,which is likely to lead to the pathogenesis of hyperoxic lung injure in premature rats.
