Changes of Plasma Pulmonary Surfactant Protein-A and Serum Ferritin in Neonates with Mechanical Ventilation
- VernacularTitle:机械通气新生儿血浆肺表面活性物质蛋白A和血清铁蛋白的变化
- Author:
xiao-ni, ZHANG
;
min, JIN
;
chao, CHEN
- Publication Type:Journal Article
- Keywords:
infant,newborn;
respiration,artificial;
pulmonary surfactants;
ferritin
- From:Journal of Applied Clinical Pediatrics
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of plasma pulmonary surfactant protein-A (SP-A) and serum ferritin (SF) in neonates with mechanical ventilation and its clinical significance in ventilation-induced lung injury (VILI).Methods The study was carried out in 36 neonates with mechanical ventilation and 31 neonates without mechanical ventilation .Plasma SP-A and SF levels in venous blood were mea- sured on 1,24,48,72 hours after mechanical ventilation and 24 hours after mechanical ventilation removal by Western-dot blot and radioimmunoassay (RIA).Plasma SP-A and SF levels of non-mechanical ventilation group were determined at the same time.Results Plasma SP-A levels in neonates on 24,48,72 hours after mechanical ventilation were significantly higher than those of non-mechanical ventilation group[( 2.20? 0.22)vs(1.97?0.29) ?g/L,(2.43?0.28)vs(1.94?0.33) ?g/L,(2.61?0.38)vs(1.80?0.34) ?g/L,respectively P
