Expression and Clinical Significance of bcl-X_L mRNA and Its Protein in Childhood Medulloblastoma
- VernacularTitle:髓母细胞瘤组织bcl-X_L mRNA和蛋白表达及临床意义
- Author:
xin-jun, WANG
;
zhong-wei, ZHAO
;
ji-xin, SHOU
;
pei-dong, LI
;
qiao, SHAN
;
quan, LIU
- Publication Type:Journal Article
- Keywords:
medulloblastoma;
bcl-XL gene;
immunohistochemistry;
in situ hybridization;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression level and clinical significance of bcl-XL gene in childhood medulloblastoma.Methods The expression of Bcl-XL protein and bcl-XL mRNA were determined by immunohistochemical staining and in situ hybridization in 41 samples of medulloblastoma tissues,as well as 20 normal brain tissues.Results The positive rate of Bcl-XL protein(90.2%) and bclXL mRNA(95.1%) in medulloblastoma group were significantly higher than those in normal human brain tissues(all P
