Changes of Insulin-Like Growth Factor-1 in Mice with Viral Myocarditis and Their Protective Effects on Myocardium
- VernacularTitle:胰岛素样生长因子-1在病毒性心肌炎小鼠中的变化及对心肌的保护作用
- Author:
jian, GU
;
yan-song, LI
;
da-bin, WANG
- Publication Type:Journal Article
- Keywords:
myocarditis,viral;
insulin-like growth factor-1;
immunohistochemistry
- From:Journal of Applied Clinical Pediatrics
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the significance of change of insulin-like growth factor-1(IGF-1) and study the effect of IGF-1 on expression of Bcl-2 and Bax.Methods Male Balb/c mice were randomly divided into control group,coxsackie B3(CVB3) infection group(infection group),CVB3 infection with IGF-1 treated group.Animals were killed at d7,d14.The immunohistochemical studies and medical imagine analysis system were performed to evaluate the expression of Bcl-2 and Bax in myocardial tissue.Serum IGF-1 concentrations were assayed by radioimmunoassay(RIA).Results In infection group,the concentrations of IGF-1 were more decreased than that of control group and the expression of Bcl-2 reduced and Bax increased(P
