Significance of Changes of Plasma Levels of Adrenomedullin and Endothelin-1 in Infants with Congenital Heart Disease Complicated with Congestive Heart Failure
- VernacularTitle:先天性心脏病并心力衰竭患儿血浆肾上腺髓质素和内皮素水平变化的意义
- Author:
ming, LU
;
ai-hua, GUO
;
yi, WU
;
chun-ping, XU
- Publication Type:Journal Article
- Keywords:
congenital heart disease;
heart failure;
adrenomedullin;
endothelin-1
- From:Journal of Applied Clinical Pediatrics
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the roles of adrenomedullin(ADM) and endothelin-1(ET-1) in left-to-right shunt congenital heart disease(CHD) complicated with congestive heart failure(CHF).Methods Plasma ADM and ET-1 concentrations were measured by radioimmunoassay in heart failure stage and recovery period of 18 infants with left-to-right shunt CHD.Also 20 healthy infants acted as control group were measured.Results Plasma concentrations of ADM and EF-1 were significantly higher in heart failure stage of left-to-right CHD infants than those in their recovery period,and both in their heart failure stage and in their recovery period were higher than that in control group(P
