Changes of Serum Interleukin-13 and Total Immunoglobulin E in Children with Stable Asthma
- VernacularTitle:哮喘缓解期儿童血清白细胞介素-13与免疫球蛋白E水平变化
- Author:
qing-ling, XIE
;
wei, JIAO
;
qiong-yan, HU
- Publication Type:Journal Article
- Keywords:
asthma;
interleukin-13;
immunoglobulin E;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of interleukin-13(IL-13) and total immunoglobulin E(IgE) levels in children with stable asthma.Methods Eighty-eight cases of children with asthma in remission stage aged 6-14 years old and 40 normal children were involved in this study.The concentrations of serum IL-13 and total IgE were measured with enzyme linked immunosorbent assay(ELISA) method and UniCAP pharmacia system.Results Clinical evaluation and lung function were improved in asthmatic children.Serum IL-13 level of asthmatic children in remission stage was higher than that of control group(U=3.93 P0.05).Conclusions There exists continuous allergic inflammation for children with asthma in remission stage.The high concentrations of serum IL-13 and IgE are associated with immune pathological mechanisms of asthma.
