Changes of Cytokines in Newborn Meconinum Aspiration Syndrome
- VernacularTitle:新生儿胎粪吸入性肺炎血清细胞因子水平的变化
- Author:
ning, DING
;
hong-bing, WANG
;
xue-ping, DONG
- Publication Type:Journal Article
- Keywords:
infant,newborn;
meconinum aspiration syndrome;
interleukin-1?;
interleukin-8;
tumor necrosis factor-?;
insulin-like growth factor-1
- From:Journal of Applied Clinical Pediatrics
2006;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate role of interleukin-1?(IL-1?),interleukin-8(IL-8),tumor necrosis factor-?((TNF-?)) and insulinlike growth factor-1(IGF-1) in meconium aspiration syndrome(MAS) in newborns.Methods The concentrations of(IL-1?),IL-8,TNF-? and IGF-1 in peripheral serum were detected in 32 newborns with MAS and 15 normal newborns by radio-immunity at the first,the third and seventh day after being born.Correlations between IGF-1 and changes of IL-1?,IL-8,TNF-? was analyzed.Results Compared with control group,the concentration of IL-1?,IL-8 and TNF-? increased significantly in newborns with MAS in three days after being born(all P0.05).On the other hand, the concentration of IGF-1 in newborns with MAS was obviously lower than that of normal newborns one week after birth.The concentration of IGF-1 showed negative correlations with that of IL-1?,IL-8 and TNF-?(r=-0.67,-0.61,-0.73 all P
