Expression of Matrix Metallproteinase-2 and Matrix Metallproteinase-9 on Aortic Valve in Children with Rheumatic Heart Disease
- VernacularTitle:风湿性心脏病患儿主动脉瓣病变组织基质金属蛋白酶-2、-9表达的意义
- Author:
yan-ping, LI
;
xiu-fen, HU
;
hong-wei, WANG
;
ping, HUANG
;
pei-xuan, CHENG
;
neng-bao, LIU
;
shao-hua, ZHU
;
xiao-heng, LI
- Publication Type:Journal Article
- Keywords:
rheumatic heart disease;
matrix metalloproteinases;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of matrix metallproteinases(MMPs) in aortic valve of children who suffered from rheumatic heart disease(RHD) and to explore the pathological role of MMPs in children′s rheumatic aortic valve disease.Methods RHD group composed of 18 aortic valves from children suffered from RHD.Controls were 8 children who were died accidentally without cardiovascular system diseases.Hematoxylin and eosin stain observing the histological characteristic of the 2 groups.Immunohistochemistry was used to detect expression of MMP2 and MMP9 on aortic valves in 2 groups.Results Hematoxylin and eosin stain showed:in RHD the valves′ structure were destroyed along with fibrous tissue proliferation,mucinous degeneration,collagen and fiber hyalinization,blood vessel and blood capillary proliferation,lymphocyte,plasmocyte,monocyte infiltration.Immunohistochemistry showed that MMP2 and MMP9 expression were significantly higher than those in the aortic of RHD(68.85?13.08,64.35?9.59) compared with control group(107.31?23.39,116.28?6.99)(t=3.92,10.18 all P
