Effect of Autoantibody Tests in Diagnosis of Autoimmune Diseases in Children
- VernacularTitle:自身抗体检测在儿童自身免疫性疾病中的意义
- Author:
qian, ZHANG
;
xiao-chuan, WANG
;
jing-yi, WANG
;
ye-heng, YU
- Publication Type:Journal Article
- Keywords:
antibodys,antinuclear;
anti-extractable nuclear antigen antibody;
anti-double strands DNA antibody;
autoantibody
- From:Journal of Applied Clinical Pediatrics
2006;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of autoantibody test which includes antinuclear antibodies(ANA),antinuclear antibody fluorescence patterns,anti-extractable nuclear antigen(ENA) antibodies and anti-double strands DNA(ds-DNA) antibodies in the diagnosis of pediactic autoimmune diseases.Methods Of all the inpatients which had positive results of autoantibody tests,135 cases were reviewed.The autoantibody assay,positive value(PV) analysis were performed respectively.Results PV of ANA test to autoimmune diseases was 0.36 which was proportional to the intensity of fluorescence;Of all the fluorescence patterns,speckled(fine) had a relatively high PV;Anti-ENA and anti-dsDNA antibody tests had higher PV than ANA test.Conclusion Fluorescence intensity,(anti-ENA) antibody test and anti-dsDNA antibody test may be useful in identifying autoimmune diseases in clinic.
