Expression and Clinical Implications of Preferentially Expressed Antigen of Melanoma Gene in Children with Acute Leukemia
- VernacularTitle:急性白血病儿童黑色素瘤特异性抗原基因表达的意义
- Author:
bao-xi, ZHANG
;
jing-lu, JI
;
xiao-qing, ZHAO
;
wen-jie, GUO
- Publication Type:Journal Article
- Keywords:
child;
acute leukemia;
preferentially expressed antigen of melanoma;
polymerase chain reaction
- From:Journal of Applied Clinical Pediatrics
2006;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05),but the expression in controls were negative.The expression levels of PRAME gene at remission was decreased obviously,but increased again when the patients relapsed.Conclusions Expression of PRAME gene has a high level in childhood acute leukemia.The dynamic changes are closely related with the prognosis.It can be regarded as a candidate for detecting minimal residual disease in acute leukemia,and may have important implications for estimating the prognosis and guiding the chemical therapy.
