Influence of Human Chorionic Gonadotropin on Testicular Germ Cell Apoptosis of Bilateral Cryptorchidism in Rats
- VernacularTitle:绒毛膜促性腺激素对双侧隐睾大鼠睾丸生殖细胞凋亡的影响
- Author:
kai-sheng, LV
;
yan-fang, REN
;
cui-ping, SONG
- Publication Type:Journal Article
- Keywords:
cryptorchidism;
germ cell;
cell apoptosis;
human chorionic gonadotropin
- From:Journal of Applied Clinical Pediatrics
2006;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of human chorionic gonadotropin on testicular germ cell apoptosis of bilateral cryptorchidism in rats.Methods Immature male rats (22 day-old Sprague Dawley) were subjected to bilateral cryptorchidism and injected with 20 U human chorionic gonadotropin from the 22th day to the 34th day every other day. Sham operation rats were as control group. At age 35 days and 60 days, rats were sacrificed for detection germ cell apoptosis by terminal- deoxynucleotidyl transferase mediated d-UTP nick end labeling (TUNEL). Results There were significant difference of apoptosis index (AI) between bilateral cryptorchidism and sham operation groups(P0.05).Conclusion AI of cryptorchidism increases and HCG addes the number of apoptotic germ cells.
