Feasibility of Leucovorin Rescue Guided with Methotrexate Plasma Concentration
- VernacularTitle:用甲氨蝶呤血浆浓度指导四氢叶酸钙解救的可行性
- Author:
li-hua, YANG
;
xin-tian, LU
- Publication Type:Journal Article
- Keywords:
leukemia,lymphoblastic,acute;
methotrexate;
leucovorin;
toxicity
- From:Journal of Applied Clinical Pediatrics
2006;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the feasibility of leucovorin(LCV) rescue protocol defined by us,we compared the plasma concentrations,toxicity,LCV doses of different high doses methotrexate(HD-MTX).Methods Seventeen children with acute lymphoblastic leukemia and 1 children with non-Hodgkin′s lymphoma were randomly treated with total 43 courses of HD-MTX.MTX plasma concentrations were measured by fluorescence polarization immuno-assay.Different LCV rescue protocols were prospectively defined for 3 kinds of HD-MTX protocols.Adjusting LCV dose by plasma MTX concentrations.Results No irreversible MTX-related toxicity was observed in all patients.Significant differences of mean steady-state plasma concentrations(Cpss) and total rescue doses were found between 3 groups(P
